IMI2-2019-17-02 - Open access chemogenomics library and chemical probes for the druggable genome

Specific Challenge:In biomedicine, discoveries arising from novel enabling technologies and reagents have garnered a quarter of the Nobel Prizes for chemistry and medicine in this century. Among the myriad of these transformative techniques and reagents, bibliometric evidence shows that pharmacological modulators (chemical and biological probes) have both the greatest scientific citation impact, the greatest sway on exploratory biomedical research, and provide the best mechanism to understand the relevance of a protein as a potential drug target. Indeed, the field of drug discovery and the development [...]