H2020-IMI2-2020-20-05: Proton versus photon therapy for oesophageal cancer - a trimodality strategy

The main objective of this topic is to examine the value of proton therapy as a treatment modality through a clinical study in oesophageal cancer. The study will compare outcomes between pencil-beam scanning proton therapy and intensity-modulated radiation therapy (IMRT). The study will determine if proton therapy in a trimodality (radiotherapy-chemotherapy-surgery) treatment; - reduces treatment-related cardio-pulmonary toxicity;- increases loco-regional tumour control and pathological complete response and the influence of dose escalation;- improves disease-free and overall survival.Type of action: [...]